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	~~~  DESCRIPTION  OF  KOCH  THERAPY  ~~~
	1.  detoxification: 
		ptomaines, certain foods,
		xenobiotics, (metals)
	2.  oxygenation
	3.  catalyst administration

	~~~   DISEASES   TREATABLE   ~~~
		allergies    70-80%
		infections   50-80%
		neoplasms    50+%
		misc.        50+%

	~~~  CATALYSTS  USED  BY  KOCH  ~~~
PARAQUINONES:    parabenzoquinone, diphenoquinone
ORTHOQUINONES:   triquinoyl, rhodozonic acid
GLYOXALS:        glyoxal, methylglyoxal, diacetyl,
                 "glyoxylide"

	~~~  SPECIAL  CHARACTERISTICS  ~~~
	=  conjugated dicarbonyl compounds 
	=  extremely dilute ( 6X to 12X ) 
	=  stable in glass ampuoles 
	=  capable of penetrating tissues 
	=  exist in three valences 
	=  redox active at an intermediate potential 
	=  capable of redox cycling in vivo 
NOTE: This is the only reaction that is repeatable 
      indefinitely and can therefore account for 
      activity at such infinitesimal doses. 

	~~~ CLASSES OF REDOX CYCLING COMPOUNDS ~~~
		1)    para-benzoquinones
		2)    para-naphthoquinones
		3)    para-anthroquinones
		4)    orthoquinones/tannins
		5)    alphaketoaldehydes &
			alphaketoketones
		6)    heterocyclic compounds
		7)    multivalent elements

	~~~  THREE  VALENCES  OF  PARAQUINONES  ~~~
                                         HC==CH
                                        /      \
       PARAQUINONE:                 O==C        C==O
         Q                              \      /
                                         HC==CH

                                         HC==CH
                                        /      \
       SEMIQUINONE:                *O--C        C--OH
        *QH                             \\    //
                                         HC--CH

                                         HC==CH
                                        /      \
       PARAHYDROQUINONE:           HO--C        C--OH
         QH2                            \\    //
                                         HC--CH

	~~~  THREE  VALENCES  OF  GLYOXALS  ~~~

   R                R              R                 R
   |      [H]       |              |       [H]       |
O==C      --->  HO--C*         HO--C       --->  HO--C
   |      [O]       |    <--->     ||      [O]       ||
   C==O  <---       C==O           C--O*  <---       C--OH
   |                |              |                 |
   R                R              R                 R

  OGO                    *OGOH                     HOGOH

EXAMPLES: glyoxal, methylglyoxal, diacetyl, "glyoxylide" 
       orthoquinones, tannins, triquinoyl, rhodizonic acid 
       dehydroascorbic acid, pyrroloquinoline quinone 

		~~~   FIVE   MECHANISMS   ~~~
Five mechanisms exist whereby redox cycling can profoundly
deplete electrons/hydrogen from various physiolic carriers:
	1)   quinone type redox cycling 
	2)   superoxide production 
	3)   hydrogen peroxide production 
	4)   autoregeneration of H2O2 
	5)   immunoactivation producing ROS 
             at the sight of pathology 

~~~ REDUCTANT DEPLETING MECHANISMS FOR QUINONES ~~~
   1.  Direct dehydrogenation of various substrates
             XH   +  Q   --->   X*   +  HQ* 
             XH2  +  Q   --->  HX*   +  HQ* 
             XH2  +  Q   --->   X    +  QH2
       followed by oxidative reactivation
             HQ*  + [O]  --->   Q    +  [HO*] 
             QH2  + [O]  --->   Q    +  H2[O]
   2.  Superoxide/hydroperoxyl radical production
            *QH  +  O2  --->  Q  +  -OO*  +  H+
            *XH  +  O2  --->  X  +  -OO*  +  H+
            HOO*  +  AOH  --->  HOOH  +  AO*
   3.  Hydrogen peroxide production
            HOO*  +  AOH  --->  AO*  +  HOOH
            2(-OO*)  +  2H+  --->  O2  +  HOOH
            2GSH  +  HOOH  --->  GSSG  +  2H2O
   4.  Autoregeneration of hydrogen peroxide
            HOOH   +  P    --->  P**
            2HXH   +  P**  --->  2HX*  +  P  +  2HOH
            2HX*   +  2OO  --->  2X  +  2-OO*  +  2H+
            2-OO*  +  2H+  --->  OO  +  HOOH
       ===  2HXH   +  OO   --->  2X  +  2HOH  ===

	~~~   REDUCTANTS   AS   SUBSTRATES   ~~~
These can lose electrons to quinones: 
	Amines:
		hydropyridines, leukoflavins
	Enediols:
		ascorbates, bioflavonoids
	Phenols:
		tocopherols, ubiquinols
	Thiols:
		glutathione, proteins
	Aldehydes
	Multivalent Metals:
		Fe++ or Cu+

	~~~   OXIDANTS   AS   RECYCLERS   ~~~
These can reoxidize semiquinones and dihydroquinones. 
	Oxygen Compounds:
		*OO* , O=O , HOOH
	Oxyradicals:
		HO* , HOO* , RO* , ROO*
	Hypochlorous Acid:   HClO
	Multivalent Metals:
		Fe+++ (peroxidases,cytochromes)
		Cu++  (ceruloplasmin)

~~~  "ENZYMES  AND  METABOLIC  INHIBITORS"  ~~~
    by  J.  Leyden  Webb,  School of Medicine, 
    University of Southern California, Los Angeles, 
Academic Press, 1966, Volume 3, Chapter 5, pp 421-594
    TOPICS DISCUSSED: 
structural formulae of quinones, effects of attached groups,
oxidation-reduction reactions, addition reactions, 
tables of enzymes inhibited, mechanisms of inhibition, 
effects on electron transport, oxidative phosphorylation, 
effects on glycolysis, respiration, metabolic systems, 
effects on tissue functions, whole animals, 
antimitotic actions, effects on neoplastic cells, 
antibacterial activity, effects on fungi, 
effects on algae, protozoa, invertebrates, viruses, 
effects of quinone like imines 

	~~~  QUINONE  TYPES  AND  EXAMPLES  ~~~

  BENZOQUINONES:    parabenzoquinone      uva ursi
      C==C          methoxybenzoquinone   wheat
     /    \         plastoquinone         algae
 O==C      C==O     ubiquinone            heart
     \    /
      C==C

  NAPTHOQUINONES:   menadione             vit K
      C==C          lapachol              pau-de-arco
     /    \         plumbagin             lead wort & VFT
 O==C      C==O     juglone               black walnut
     \    /         lawsone               henna
      RING

  ANTHROQUINONES:   emodin                senna & cascara
      RING          aloe-emodin           aloe vera rind
     /    \         rhein                 rhubarb root
 O==C      C==O     hypericin             St.John's wort
     \    /
      RING

"In vitro stimulation of human granulocytes and lymphocytes 
 by pico- and femtogram quantities of cytostatic agents" 
	by Wagner H, Kreher B, Jurcic K
	Arzneimittel-Forschung 38(1): 273-275 (1988)

    DOSAGE RANGES:                 RESULTS:
     mg to ug                       cytotoxic
     ug to ng                       suppressive
     ng to pg                       null
     pg to fg                       stimulatory
     fg to ag                       null

 These results correspond to concentrations calculable 
 in vivo after injection of a Koch catalyst. 

	~~~   HINDERING   AGENTS   ~~~
1) amines such as methylguanidine
   inhibit diamine oxidase
   may inhibit carbonyl compounds in other BETS
2) sulfides especially hydrogen sulfide
   like cyanide strongly inhibit cytochrome A
3) toxic metals such as selenite overdose
   bind to thiols so as to block electron transfers
4) citrus fruit
   contains citric acid which inhibits ceruloplasmin
   may supply turpenes from the rind 
5) xenobiotic detox stimulants: 
  (e.g. alcohols, turpenes, aromatics, organic chlorides)
enhance phase II conjugases & accelerate catalyst removal
eliminate glutathione by induction of S-transferases 
induce synthesis of quinone reductases & CP450 reductases 
6) grapes
   contains resveratrol which induces quinone reductase

~~~  HOW TO OVERCOME XENOBIOTIC INTERFERENCE ~~~
Select patients which are: 
	not already exposed excessively 
	not in need of many detox stimulating 
		drugs, foods, or herbs 
	not in a hyperactive detox condition 
For those deemed in need of xenobiotics: 
	minimize exposure or utilization 
	treat nutritionally to ensure 
		sufficiency of GSH 
	repeat catalyst administration more often 
	switch to stronger oxidant therapies 
		(e.g.  O3, ClO2, H2O2, UVHIT) 

	~~~   ENHANCING   AGENTS   ~~~
The following were found to supportive of recovery 
per clinical experience of Dr. Koch:
* nutrition             * PUFA's           * oxygenation 
* colon detoxification  * copper           * acute infection 
* hydrogen peroxide     * hemoirradiation  * magnetic fields 

	~~~  WHAT  ABOUT  COFFEE  ENEMAS ?  ~~~
Several alternative health programs involve 
  the regular administration of coffee enemas. 
This is thought by many to detoxify the liver 
  as caffeine stimulates bile flow. 
However, the roasting of coffee beans is known to produce: 
  glyoxal, methylglyoxal, diacetyl, 
  and other dicarbonyl compounds. 
Brewing is known to produce orthoquinones and 
  hydrogen peroxide, as caffeic acid and other 
  polyphenols auto-oxidize. 
	polyphenol + O2 ---> orthoquinone + H2O2 
Thus brewed coffee is a mixture of glyoxals, orthoquinones, 
  and hydrogen peroxide, all of which are pro-oxidant. 
Much of the immune system is present in the lymphoid 
  tissues of the gut, which would be in close proximity 
  to the coffee. 
This suggests that the real value of coffee enemas may be 
  oxidative stimulation of the immune system of the gut. 
This would be similar in principle to rectal insufflation 
  of ozone, a known effective method. 
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