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PRECAUTIONS ABOUT EXPOSURE OF CHLORINE DIOXIDE
TO CERTAIN ANTIOXIDANTS AND AMINES,
WHICH DISABLE EFFICACY
Copyright 2025 by Thomas Lee Hesselink, MD
However reproduction and distribution for educational,
free speech and research purposes is permitted and encouraged.
ITEMS THAT REACT WITH CHLORINE DIOXIDE
As a student of chemistry, I have particular concerns with some issues that can be or are often overlooked about ClO2.

Being a rapidly acting molecule, this explains ClO2's ability to kill pathogens. However, the same chemical reactivity that enables this also makes ClO2 uniquely vulnerable to quenching and to failure. To be specific I draw attention to the 5 main targets of reactivity, namely: thiols, phenols, enediols (such as ascorbate), secondary amines, and tertiary amines. Molecules of these types are essential to life in all species. These are denatured rapidly by reaction with ClO2. Hence the sudden death of all pathogens, which are unable cope with such a sudden loss of essential components. The reason the host organism is little effected is that it has these molecules in greater abundance and can rapidly replace whatever is lost. Thus the pathogen dies and the host survives suffering only minor and transient side-effects.

Overlooked Issues
Because of these reactivities, there is an easy and often overlooked way to defeat the efficacy of orally consumed acidified sodium chlorite (ASC) or chlorine dioxide solution (CDS). That would be to permit these quenching substances to mix together in the solution or in the stomach at the time of ingestion.
Protein
Any protein in the solution or in the stomach will defeat efficacy. Proteins present reactive groups, namely: cysteine (a thiol), tyrosine (a phenol), tryptophan and proline (both secondary amines).
Most Drugs
Most drugs contain secondary or tertiary amines and therefore should be administered hours before or after, not together with the solutions. Examples would be allopurinol, fenbendazole, metformin, and hydroxychloroquine. (As an aside, I conject that ClO2 would in theory be an excellent antidote for fentanyl poisoning, as fentanyl has 2 tertiary amines making it vulnerable to destruction. However this could easily fail because fentanyl is so fast acting.)

Some drugs such as DMSA, captopril or mesna are thiols. Estradiol and methyldopa are phenols. Aniline based drugs such as acetaminophen, furosemide and sulfisoxazole are also reactive with ClO2. To inquire pertaining to the reactive groups of drugs one can search Go Drug Bank. The easiest route is just not to take any meds with ASC or CDS.

Supplements
The same problems hold true for many supplements. For example alpha-lipoic-acid and N-acetyl-L-cysteine are thiols. Garlic, onions, asparagus and cilantro are rich in thiols.

B-complex vitamins such as thiamine, riboflavin, pantothenate, and folate contain reactive amines. So does melatonin. PABA is an aniline derivative.

Pyridoxine, all tocopherols and all bioflavonoids are phenols. For example: quercetin (as from apples and onions), catechins (as from green tea), capsaicin (as from red pepper) and curcuminoids (as from turmeric) are all phenols. This is why I do not recommend flavoring ClO2 solutions with any kind of fruit juice, as all fruits are rich sources of phenolic antioxidants.

Similarly ascorbates and all enediols (as in many bioflavonoids) easily quench ClO2.

Timing
To optimize efficacy therefore the user of ClO2 solutions (ASC or CDS) who plans to also take quenching substances must separate these in time. Wait several hours after taking quenchers before ingesting solution, never take quenchers together with solution, and wait a few hours after solution to resume any quenchers. These precautions should be included with any discussions about how to properly use ClO2 solutions orally.
Disclaimers
Due to the potential of legal problems and liabilities,
no guarantees, nor doctor-patient relationships,
nor medical advice, nor labeling, nor medical obligations
of any kind are herein set forth or held out.
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