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~~~ A QUESTION OF DOSIMETRY ~~~
How much oxidation is enough?
How much oxidation is too much?
Foci of redosis favor allergy, infection, cancer.
Oxystress destroys healthy cells, organelles,
and biological molecules.
Optimal health is associated with neither
an extreme oxidosis nor an extreme redosis.
Regular shifting of conditions between mild redosis
and mild oxidosis is probably optimal.
Thus physiologic processes, which function optimally
under one condition or the other, should be
facilitated best in alternate phases.
~~~ HOW TO ADMINISTER OXIDATIVE THERAPIES ~~~
This varies with the kind of oxidant used.
Special attention is needed pertaining to
quality and stability.
Hydrogen peroxide lasts several months,
whereas ozone is gone after a few hours.
Some tissues are especially sensitive to certain
oxidants and tolerate others well.
Examples of special tissue sensitivities:
lungs - - - - - ozone
stomach - - - - hydrogen peroxide
skin & eyes - - ultraviolet
The following suggests possible administrations,
but should not be used as a treatment guide.
Information in this regard is controversial
and changable over time.
OXIDANT: AHT: IV: IM/IT: PO: Aero: Top:
ozone Y ? Y Y N Y
chlorine dioxide ? Y ? Y N Y
hypochlorite ? ? ? ? N Y
chlorite ? ? ? ? N Y
H2O2 N Y ? ? ? Y
MgO2 N ? ? Y N Y
ZnO2 N ? ? ? N Y
HBOxygen N N N N Y Y
UV radiation Y ? Y N N ?
direct current ? Y Y N N Y
nitrate N ? ? Y N Y
Permanganate N N N N N Y
iodine N N N ? N Y
p-Quinones ? Y Y Y Y Y
Glyoxals ? Y Y Y Y Y
DHAA ? N ? ? ? ?
o-Quinones ? ? ? ? ? Y
org.ozonides N ? Y ? N Y
org.peroxides N ? ? ? N Y
imidazoles N Y Y Y ? Y
meth-blue N Y ? Y ? ?
~~~ RELEVENCE TO OTHER THERAPIES ~~~
ascorbic acid or sodium ascorbate:
conversion to DHAA causes cytotoxicity to tumors
production of superoxide & hydrogen peroxide
fasting or hydrazine sulfate:
low or normal glycemia fails
to support growth of pathogens
such as bacteria or tumors
N-acetyl-L-cysteine or whey:
antiviral agent, heavy metal trap,
cofactor for GPrx & T4 to T3 conversion
oxidants enhance radiosensitivity
heavy metals enhance oxyradical stress
heavy metals inhibit systemic immunity
intracellular alkalinity makes thiols
more sensitive to oxidation
inhibits glucose-6-phosphate dehydrogenase
consumes reducing equivalents
quinone reductase inhibitors:
may enhance levels of quinones in the
reduced phase enabling them to serve
as medicinal oxidants
although alkylating also inhibit GSH
reductase causing intracellular oxidosis
cofactor for numerous oxidative enzymes
eliminates hydrogen sulfide which otherwise
inhibits copper enzymes e.g. cytochrome A
inhibits pyridine reductases in bacteria
might facilitate certain redox reactions
might open pi bonds causing oxidation
~~~ SUMMARY COMMENTS ~~~
Oxidative therapies are widely applicable in medical practice,
especially in infectious disease, in oncology, and in allergy.
The goals of oxidative medicine are:
1) to shift redox potentials away from a pro-reductant
condition (redosis), temporarily towards a mildly
pro-oxidant condition (oxidosis).
2) to induce beneficial physiologic responses.
Fairly low doses of medicinal oxidants are usually administered.
Free radical stress or damage to host tissues is not
a necessary nor a desired effect of oxidative therapy.
Altered immune function is probably the most clinically
important benefit of oxidative therapy.