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	~~~  A  QUESTION  OF  DOSIMETRY  ~~~
QUESTIONS: 
	How much oxidation is enough? 
	How much oxidation is too much? 
ANSWERS: 
	Foci of redosis favor allergy, infection, cancer. 
	Oxystress destroys healthy cells, organelles, 
		and biological molecules. 
	Optimal health is associated with neither 
		an extreme oxidosis nor an extreme redosis. 
	Regular shifting of conditions between mild redosis 
		and mild oxidosis is probably optimal. 
	Thus physiologic processes, which function optimally 
		under one condition or the other, should be 
		facilitated best in alternate phases. 

          ~~~  FOUR  ZONES  OF  REDOX  STATUS  ~~~

      * * * * * * * * * * * * * * * * * * * * * * * * *
      *           *           *           *           *
      *     1     *     2     *     3     *     4     *
      *           *           *           *           *
      * * * * * * * * * * * * * * * * * * * * * * * * *
        REDOSIS     BALANCE     OXIDOSIS    OXYSTRESS
        sedated     rested      exercised   exhausted
        overfed     fed         fasted      starved

	~~~  HOW TO ADMINISTER OXIDATIVE THERAPIES  ~~~
	This varies with the kind of oxidant used. 
	Special attention is needed pertaining to 
		quality and stability. 
	Hydrogen peroxide lasts several months, 
		whereas ozone is gone after a few hours. 
	Some tissues are especially sensitive to certain 
		oxidants and tolerate others well. 
	Examples of special tissue sensitivities: 
		lungs - - - - - ozone 
		stomach - - - - hydrogen peroxide 
		skin & eyes - - ultraviolet 
	The following suggests possible administrations, 
		but should not be used as a treatment guide. 
	Information in this regard is controversial 
		and changable over time. 
OXIDANT:          AHT:  IV:  IM/IT: PO:  Aero:  Top: 
ozone              Y     ?     Y     Y     N     Y
chlorine dioxide   ?     Y     ?     Y     N     Y
hypochlorite       ?     ?     ?     ?     N     Y
chlorite           ?     ?     ?     ?     N     Y
H2O2               N     Y     ?     ?     ?     Y
MgO2               N     ?     ?     Y     N     Y
ZnO2               N     ?     ?     ?     N     Y
HBOxygen           N     N     N     N     Y     Y
UV radiation       Y     ?     Y     N     N     ?
direct current     ?     Y     Y     N     N     Y
nitrate            N     ?     ?     Y     N     Y
Permanganate       N     N     N     N     N     Y
iodine             N     N     N     ?     N     Y
p-Quinones         ?     Y     Y     Y     Y     Y
Glyoxals           ?     Y     Y     Y     Y     Y
DHAA               ?     N     ?     ?     ?     ?
o-Quinones         ?     ?     ?     ?     ?     Y
org.ozonides       N     ?     Y     ?     N     Y
org.peroxides      N     ?     ?     ?     N     Y
imidazoles         N     Y     Y     Y     ?     Y
meth-blue          N     Y     ?     Y     ?     ?

   ~~~  RELEVENCE  TO  OTHER  THERAPIES  ~~~
ascorbic acid or sodium ascorbate: 
	conversion to DHAA causes cytotoxicity to tumors 
	production of superoxide & hydrogen peroxide 
fasting or hydrazine sulfate: 
	low or normal glycemia fails 
	to support growth of pathogens 
	such as bacteria or tumors 
N-acetyl-L-cysteine or whey: 
	replenishes glutathione 
selenium: 
	antiviral agent, heavy metal trap, 
	cofactor for GPrx & T4 to T3 conversion 
radiation: 
	oxidants enhance radiosensitivity 
mercury detoxification: 
	heavy metals enhance oxyradical stress 
	heavy metals inhibit systemic immunity 
cesium chloride: 
	intracellular alkalinity makes thiols 
	more sensitive to oxidation 
DHEA: 
	inhibits glucose-6-phosphate dehydrogenase 
thyroid: 
	consumes reducing equivalents 
quinone reductase inhibitors: 
	may enhance levels of quinones in the 
	reduced phase enabling them to serve 
	as medicinal oxidants 
nitrosoureas: 
	although alkylating also inhibit GSH 
	reductase causing intracellular oxidosis 
copper: 
	cofactor for numerous oxidative enzymes 
colon detoxification: 
	eliminates hydrogen sulfide which otherwise 
        inhibits copper enzymes e.g. cytochrome A 
silver: 
	inhibits pyridine reductases in bacteria 
magnetic fields: 
	might facilitate certain redox reactions 
light/color therapies: 
	might open pi bonds causing oxidation 

              ~~~   SUMMARY   COMMENTS   ~~~
Oxidative therapies are widely applicable in medical practice, 
  especially in infectious disease, in oncology, and in allergy. 
The goals of oxidative medicine are: 
  1) to shift redox potentials away from a pro-reductant 
     condition (redosis), temporarily towards a mildly 
     pro-oxidant condition (oxidosis). 
  2) to induce beneficial physiologic responses. 
Fairly low doses of medicinal oxidants are usually administered. 
Free radical stress or damage to host tissues is not 
  a necessary nor a desired effect of oxidative therapy. 
Altered immune function is probably the most clinically 
  important benefit of oxidative therapy.
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