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~~~ WHAT IS OXIDATIVE THERAPY ~~~
1- the administration of oxidants
in the treatment of illness or
for other healthful purposes;
2- the promoting, accelerating,
supplementing, or stimulating
of oxidative processes in the body.
~~~ USUAL INDICATIONS FOR OXIDATIVE THERAPY ~~~
~~~ OXIDATIVE THERAPY =/= FREE RADICAL STRESS ~~~
"Oxidative Therapy" is NOT the same as "Free Radical Stress".
Oxidative Therapy is not meant to be destructive.
Safe physiologic changes are preferred, such as:
- a shift in redox potential,
- altered utilization of reducing equivalents,
- on/off switching of cellular controls
Free Radical Stress is characterized by:
- a toxic overabundance of oxyradicals,
- damage to biomolecules and to cellular structures
~~~ MYTHS PERTAINING TO BIOLOGICAL OXIDATION ~~~
1- Many oxyradicals are 1- Therefore all oxidants are
strong oxidants and toxic. toxic just like oxyradicals.
2- Oxyradicals are free 2- Therefore all free
radicals and often toxic. radicals are toxic.
3- Certain quenchers of 3- Therefore a reductant overload
oxyradicals are reductants. is beneficial to eliminate as
many oxidants as possible.
~~~ TRUTHS PERTAINING TO OXIDANTS AND FREE RADICALS ~~~
1. THERE ARE GOOD OXIDANTS:
cytochromes, ubiquinone, flavoproteins,
pyridinium nucleotides, amine oxidases,
pyrroloquinoline quinone, disulfides,
diatomic oxygen, hydrogen peroxide, etc.
2. THERE ARE GOOD FREE RADICALS:
semioxidized ascorbate, semireduced flavins,
tocopheryl, nitric oxide, superoxide, etc.
3. THERE ARE BAD REDUCTANTS:
hyperglycemia, acetaldehyde, tyramine,
ferrous iron, methyl mercury, etc.
~~~ OXYGENATION VERSUS OXIDATION ~~~
The physiologic process of absorbing diatomic
oxygen (O2) and delivering it to tissues.
The physiologic process of accepting,
taking up, or removing electrons.
~~~ FACTORS WHICH INHIBIT OXYGENATION ~~~
- Poor Air Quality
- High Altitude
- Poor Lung Function
- RBC Clumping
- Arterial Stenosis
- Arteriolar Vasospasm
- Capillary Endothelial Swelling
- Fibrin Layering
- Basement Membrane Thickening
- Tissue Swelling
- Cytochrome A3 Dysfunction
CO, CN-, HS-, NN-